Fc-fusion proteins and FcRn: structural insights for longer-lasting and more effective therapeutics

Nearly 350 IgG-based therapeutics are approved for clinical use or are under development for many diseases lacking adequate treatment options. These include molecularly engineered biologicals comprising the IgG Fc-domain fused to various effector molecules (so-called Fc-fusion proteins) that confer...

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Bibliografiska uppgifter
I publikationen:Crit Rev Biotechnol
Huvudupphovsmän: Rath, Timo, Baker, Kristi, Dumont, Jennifer A., Peters, Robert T., Jiang, Haiyan, Qiao, Shuo-Wang, Lencer, Wayne I., Pierce, Glenn F., Blumberg, Richard S.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2013
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4876602/
https://ncbi.nlm.nih.gov/pubmed/24156398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/07388551.2013.834293
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