Brief Report: HIV-1 Evolution in Breakthrough Infections in a Human Trial of Oral Pre-exposure Prophylaxis With Emtricitabine and Tenofovir Disoproxil Fumarate

We describe HIV-1 evolutionary dynamics in the 4 participants from the TDF2-PrEP trial who became HIV-1 infected while prescribed emtricitabine and tenofovir disoproxil fumarate (FTC/TDF). At seroconversion, virus diversity in the 2 participants with detectable drug was only 0.05% (95% confidence in...

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Vydáno v:J Acquir Immune Defic Syndr
Hlavní autoři: Ruone, Susan, Paxton, Lynn, McLaurin, Tony, Taylor, Allan, Hanson, Debra, Heneine, Walid, Brooks, John T., García-Lerma, José Gerardo
Médium: Artigo
Jazyk:Inglês
Vydáno: JAIDS Journal of Acquired Immune Deficiency Syndromes 2016
Témata:
Basic and Translational Science
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4876572/
https://ncbi.nlm.nih.gov/pubmed/26689970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/QAI.0000000000000921
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