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comets (Constrained Optimization of Multistate Energies by Tree Search): A Provable and Efficient Protein Design Algorithm to Optimize Binding Affinity and Specificity with Respect to Sequence
Practical protein design problems require designing sequences with a combination of affinity, stability, and specificity requirements. Multistate protein design algorithms model multiple structural or binding “states” of a protein to address these requirements. comets provides a new level of versati...
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| Published in: | J Comput Biol |
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| Main Authors: | , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
Mary Ann Liebert, Inc.
2016
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4876521/ https://ncbi.nlm.nih.gov/pubmed/26761641 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/cmb.2015.0188 |
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