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BBK* (Branch and Bound Over K*): A Provable and Efficient Ensemble-Based Protein Design Algorithm to Optimize Stability and Binding Affinity Over Large Sequence Spaces
Computational protein design (CPD) algorithms that compute binding affinity, K(a), search for sequences with an energetically favorable free energy of binding. Recent work shows that three principles improve the biological accuracy of CPD: ensemble-based design, continuous flexibility of backbone an...
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| Publicado no: | J Comput Biol |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Mary Ann Liebert, Inc.
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6074059/ https://ncbi.nlm.nih.gov/pubmed/29641249 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/cmb.2017.0267 |
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