Small molecule activation of NOTCH signaling inhibits acute myeloid leukemia

Aberrant activation of the NOTCH signaling pathway is crucial for the onset and progression of T cell leukemia. Yet recent studies also suggest a tumor suppressive role of NOTCH signaling in acute myeloid leukemia (AML) and reactivation of this pathway offers an attractive opportunity for anti-AML t...

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Pubblicato in:Sci Rep
Autori principali: Ye, Qi, Jiang, Jue, Zhan, Guanqun, Yan, Wanyao, Huang, Liang, Hu, Yufeng, Su, Hexiu, Tong, Qingyi, Yue, Ming, Li, Hua, Yao, Guangmin, Zhang, Yonghui, Liu, Hudan
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4876435/
https://ncbi.nlm.nih.gov/pubmed/27211848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep26510
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