Structure of the Dictyostelium Myosin-II Heavy Chain Kinase A (MHCK-A) α-kinase domain apoenzyme reveals a novel autoinhibited conformation

The α-kinases are a family of a typical protein kinases present in organisms ranging from protozoa to mammals. Here we report an autoinhibited conformation for the α-kinase domain of Dictyostelium myosin-II heavy chain kinase A (MHCK-A) in which nucleotide binding to the catalytic cleft, located at...

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Vydáno v:Sci Rep
Hlavní autoři: Ye, Qilu, Yang, Yidai, van Staalduinen, Laura, Crawley, Scott William, Liu, Linda, Brennan, Stephanie, Côté, Graham P., Jia, Zongchao
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4876393/
https://ncbi.nlm.nih.gov/pubmed/27211275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep26634
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