Autophosphorylation Activates Dictyostelium Myosin II Heavy Chain Kinase A by Providing a Ligand for an Allosteric Binding Site in the α-Kinase Domain

Dictyostelium discoideum myosin II heavy chain kinase A (MHCK A), a member of the atypical α-kinase family, phosphorylates sites in the myosin II tail that block filament assembly. Here we show that the catalytic activity of A-CAT, the α-kinase domain of MHCK A (residues 552–841), is severely inhibi...

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Detalhes bibliográficos
Main Authors: Crawley, Scott W., Gharaei, Mojdeh Samimi, Ye, Qilu, Yang, Yidai, Raveh, Barak, London, Nir, Schueler-Furman, Ora, Jia, Zongchao, Côté, Graham P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Enzymology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3024756/
https://ncbi.nlm.nih.gov/pubmed/21071445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.177014
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