Abrogation of collagen-induced arthritis by a peptidyl arginine deiminase inhibitor is associated with modulation of T cell-mediated immune responses

Proteins containing citrulline, a post-translational modification of arginine, are generated by peptidyl arginine deiminases (PAD). Citrullinated proteins have pro-inflammatory effects in both innate and adaptive immune responses. Here, we examine the therapeutic effects in collagen-induced arthriti...

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Publicado no:Sci Rep
Main Authors: Kawalkowska, Joanna, Quirke, Anne-Marie, Ghari, Fatemeh, Davis, Simon, Subramanian, Venkataraman, Thompson, Paul R., Williams, Richard O., Fischer, Roman, La Thangue, Nicholas B., Venables, Patrick J.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4876390/
https://ncbi.nlm.nih.gov/pubmed/27210478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep26430
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