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Mechanism of isoniazid‐induced hepatotoxicity: then and now

Isoniazid (INH) remains a mainstay for the treatment of tuberculosis despite the fact that it can cause liver failure. Previous mechanistic hypotheses have classified this type of drug‐induced liver injury (DILI) as ‘metabolic idiosyncrasy’ which was thought not to involve an immune response and was...

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Detalhes bibliográficos
Publicado no:Br J Clin Pharmacol
Main Authors: Metushi, Imir, Uetrecht, Jack, Phillips, Elizabeth
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4876174/
https://ncbi.nlm.nih.gov/pubmed/26773235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12885
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