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Mechanism of isoniazid‐induced hepatotoxicity: then and now

Isoniazid (INH) remains a mainstay for the treatment of tuberculosis despite the fact that it can cause liver failure. Previous mechanistic hypotheses have classified this type of drug‐induced liver injury (DILI) as ‘metabolic idiosyncrasy’ which was thought not to involve an immune response and was...

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Vydáno v:Br J Clin Pharmacol
Hlavní autoři: Metushi, Imir, Uetrecht, Jack, Phillips, Elizabeth
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2016
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4876174/
https://ncbi.nlm.nih.gov/pubmed/26773235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12885
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