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Relating Essential Proteins To Drug Side-Effects Using Canonical Component Analysis: A Structure-Based Approach

The molecular mechanism of many drug side-effects is unknown and difficult to predict. Previous methods for explaining side effects have focused on known drug targets and their pathways. However, low affinity binding to proteins that are not usually considered drug targets may also drive side-effect...

Täydet tiedot

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Bibliografiset tiedot
Julkaisussa:J Chem Inf Model
Päätekijät: Liu, Tianyun, Altman, Russ B
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2015
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4875781/
https://ncbi.nlm.nih.gov/pubmed/26121262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jcim.5b00030
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