Affinity maturation of anti-TNF-alpha scFv with somatic hypermutation in non-B cells

Activation-induced cytidine deaminase (AID) is required for the generation of antibody diversity through initiating both somatic hypermutation (SHM) and class switch recombination. A few research groups have successfully used the feature of AID for generating mutant libraries in directed evolution o...

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Bibliographic Details
Published in:Protein Cell
Main Authors: Chen, Shaopeng, Qiu, Junkang, Chen, Chuan, Liu, Chunchun, Liu, Yuheng, An, Lili, Jia, Junying, Tang, Jie, Wu, Lijun, Hang, Haiying
Format: Artigo
Language:Inglês
Published: Higher Education Press 2012
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4875482/
https://ncbi.nlm.nih.gov/pubmed/22467272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13238-012-2024-7
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