Combined effects of p53 and MDM2 polymorphisms on susceptibility and surgical prognosis in hepatitis B virus-related hepatocellular carcinoma

The p53 signaling pathway works as a potent barrier to tumor progression. Two single nucleotide polymorphisms (SNPs) in the gene loci of p53 pathway, p53 codon 72 Arg72Pro and MDM2 SNP309 (T > G), have been shown to cause perturbation of p53 function, but the effect of the two SNPs on the risk of...

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書目詳細資料
發表在:Protein Cell
Main Authors: Yang, Yun, Xia, Tian, Li, Ning, Zhang, Jin, Yang, Yuan, Cong, Wenming, Deng, Qiang, Lan, Ke, Zhou, Weiping
格式: Artigo
語言:Inglês
出版: Higher Education Press 2012
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4875440/
https://ncbi.nlm.nih.gov/pubmed/23292895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13238-012-2067-9
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