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PTEN inhibits PREX2-catalyzed activation of RAC1 to restrain tumor cell invasion
The tumor suppressor PTEN restrains cell migration and invasion by a mechanism that is independent of inhibition of the PI3K pathway and decreased activation of the kinase AKT. PREX2, a widely distributed GEF that activates the GTPase RAC1, binds to and inhibits PTEN. We used mouse embryonic fibrobl...
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| Publié dans: | Sci Signal |
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| Auteurs principaux: | , , , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2015
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4874664/ https://ncbi.nlm.nih.gov/pubmed/25829446 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2005840 |
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