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PRDM14 promotes RAG-dependent Notch1 driver mutations in mouse T-ALL

PRDM14 is an epigenetic regulator known for maintaining embryonic stem cell identity and resetting potency in primordial germ cells. However, hematopoietic expression of Prdm14 at supraphysiological levels results in fully penetrant and rapid-onset T-cell acute lymphoblastic leukemia (T-ALL) in the...

詳細記述

保存先:
書誌詳細
出版年:Biol Open
主要な著者: Carofino, Brandi L., Ayanga, Bernard, Tracey, Lauren J., Brooke-Bisschop, Travis, Justice, Monica J.
フォーマット: Artigo
言語:Inglês
出版事項: The Company of Biologists Ltd 2016
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4874358/
https://ncbi.nlm.nih.gov/pubmed/27106930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/bio.017699
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