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PRDM14 promotes RAG-dependent Notch1 driver mutations in mouse T-ALL
PRDM14 is an epigenetic regulator known for maintaining embryonic stem cell identity and resetting potency in primordial germ cells. However, hematopoietic expression of Prdm14 at supraphysiological levels results in fully penetrant and rapid-onset T-cell acute lymphoblastic leukemia (T-ALL) in the...
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| 出版年: | Biol Open |
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| 主要な著者: | , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
The Company of Biologists Ltd
2016
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4874358/ https://ncbi.nlm.nih.gov/pubmed/27106930 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/bio.017699 |
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