LXR Agonism Upregulates the Macrophage ABCA1/Syntrophin Protein Complex That Can Bind ApoA-I and Stabilized ABCA1 Protein, but Complex Loss Does Not Inhibit Lipid Efflux

Macrophage ABCA1 effluxes lipid and has anti-inflammatory activity. The syntrophins, which are cytoplasmic PDZ protein scaffolding factors, can bind ABCA1 and modulate its activity. However, many or “much” of the data assessing the function of the ABCA1–syntrophin interaction are based on overexpres...

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Publicado en:Biochemistry
Autores principales: Tamehiro, Norimasa, Park, Min Hi, Hawxhurst, Victoria, Nagpal, Kamalpreet, Adams, Marv E., Zannis, Vassilis I., Golenbock, Douglas T., Fitzgerald, Michael L.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4874254/
https://ncbi.nlm.nih.gov/pubmed/26506427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.5b00894
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