Low expression of pro-apoptotic Bcl-2 family proteins sets the apoptotic threshold in Waldenström Macroglobulinemia

Waldenström Macroglobulinemia (WM) is a proliferative disorder of IgM secreting, lymphoplasmacytoid cells that inhabit the lymph nodes and bone marrow. The disease carries a high prevalence of activating mutations in MyD88 (91%) and CXCR4 (28%). Because signaling through these pathways leads to Bcl-...

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Pubblicato in:Oncogene
Autori principali: Gaudette, Brian T., Dwivedi, Bhakti, Chitta, Kasyapa S., Poulain, Stéphanie, Powell, Doris, Vertino, Paula, Leleu, Xavier, Lonial, Sagar, Chanan-Khan, Asher A., Kowalski, Jeanne, Boise, Lawrence H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4874246/
https://ncbi.nlm.nih.gov/pubmed/25893290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2015.103
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