HIF-1α-PDK1 axis-induced active glycolysis plays an essential role in macrophage migratory capacity

In severely hypoxic condition, HIF-1α-mediated induction of Pdk1 was found to regulate glucose oxidation by preventing the entry of pyruvate into the tricarboxylic cycle. Monocyte-derived macrophages, however, encounter a gradual decrease in oxygen availability during its migration process in inflam...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Semba, Hiroaki, Takeda, Norihiko, Isagawa, Takayuki, Sugiura, Yuki, Honda, Kurara, Wake, Masaki, Miyazawa, Hidenobu, Yamaguchi, Yoshifumi, Miura, Masayuki, Jenkins, Dana M. R., Choi, Hyunsung, Kim, Jung-whan, Asagiri, Masataka, Cowburn, Andrew S., Abe, Hajime, Soma, Katsura, Koyama, Katsuhiro, Katoh, Manami, Sayama, Keimon, Goda, Nobuhito, Johnson, Randall S., Manabe, Ichiro, Nagai, Ryozo, Komuro, Issei
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4873978/
https://ncbi.nlm.nih.gov/pubmed/27189088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms11635
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