Experimental priming of encephalitogenic Th1/Th17 cells requires pertussis toxin-driven IL-1β production by myeloid cells

CD4(+) Th17 are heterogeneous in terms of cytokine production and capacity to initiate autoimmune diseases, such as experimental autoimmune encephalomyelitis (EAE). Here we demonstrate that experimental priming of encephalitogenic Th cells expressing RORγt and T-bet and producing IL-17A, IFN-γ and G...

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Bibliografske podrobnosti
izdano v:Nat Commun
Main Authors: Ronchi, Francesca, Basso, Camilla, Preite, Silvia, Reboldi, Andrea, Baumjohann, Dirk, Perlini, Luana, Lanzavecchia, Antonio, Sallusto, Federica
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2016
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4873938/
https://ncbi.nlm.nih.gov/pubmed/27189410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms11541
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