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Coevolution analysis of Hepatitis C virus genome to identify the structural and functional dependency network of viral proteins

A novel computational approach of coevolution analysis allowed us to reconstruct the protein-protein interaction network of the Hepatitis C Virus (HCV) at the residue resolution. For the first time, coevolution analysis of an entire viral genome was realized, based on a limited set of protein sequen...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Champeimont, Raphaël, Laine, Elodie, Hu, Shuang-Wei, Penin, Francois, Carbone, Alessandra
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4873791/
https://ncbi.nlm.nih.gov/pubmed/27198619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep26401
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