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Pseudomonas aeruginosa elastase cleaves a C-terminal peptide from human thrombin that inhibits host inflammatory responses

Pseudomonas aeruginosa is an opportunistic pathogen known for its immune evasive abilities amongst others by degradation of a large variety of host proteins. Here we show that digestion of thrombin by P. aeruginosa elastase leads to the release of the C-terminal thrombin-derived peptide FYT21, which...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: van der Plas, Mariena J. A., Bhongir, Ravi K. V., Kjellström, Sven, Siller, Helena, Kasetty, Gopinath, Mörgelin, Matthias, Schmidtchen, Artur
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4873665/
https://ncbi.nlm.nih.gov/pubmed/27181065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms11567
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