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In vivo modulation of the behavioral effects of nicotine by the coumarins xanthotoxin, bergapten, and umbelliferone
RATIONALE: Nicotine, a dominant alkaloid found in tobacco, is responsible for physical dependence, as well as addiction to cigarette smoking; consequently, smoking cessation is a very difficult process. Hepatic cytochrome P-450 2A6 (CYP2A6) is involved in the 70–80 % of the initial metabolism of nic...
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| Опубликовано в: : | Psychopharmacology (Berl) |
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| Главные авторы: | , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Springer Berlin Heidelberg
2016
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4873531/ https://ncbi.nlm.nih.gov/pubmed/27080866 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00213-016-4279-9 |
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