CK2α' Drives Lung Cancer Metastasis by Targeting BRMS1 Nuclear Export and Degradation

Breast cancer metastasis suppressor 1 (BRMS1) is decreased in non–small cell lung cancer (NSCLC) and other solid tumors, and its loss correlates with increased metastases. We show that BRMS1 is posttranslationally regulated by tumor necrosis factor–induced casein kinase 2 catalytic subunit (CK2α...

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Veröffentlicht in:Cancer Res
Hauptverfasser: Liu, Yuan, Amin, Elianna B., Mayo, Marty W., Chudgar, Neel P., Bucciarelli, Peter R., Kadota, Kyuichi, Adusumilli, Prasad S., Jones, David R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4873401/
https://ncbi.nlm.nih.gov/pubmed/26980766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-15-2888
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