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SPARC independent delivery of nab-paclitaxel without depleting tumor stroma in patient-derived pancreatic cancer xenografts

The study goal was to examine the relationship between nab-paclitaxel delivery and SPARC (secreted protein acidic and rich in cysteine) expression in pancreatic tumor xenografts and to determine the anti-stromal effect of nab-paclitaxel, which may affect tumor vascular perfusion. SPARC positive and...

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Detalhes bibliográficos
Publicado no:Mol Cancer Ther
Main Authors: Kim, Harrison, Samuel, Sharon L., Lopez-Casas, Pedro P., Grizzle, William E., Hidalgo, Manuel, Kovar, Joy, Oelschlager, Denise K., Zinn, Kurt R., Warram, Jason M., Buchsbaum, Donald J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4873363/
https://ncbi.nlm.nih.gov/pubmed/26832793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-15-0764
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