Commensal Bifidobacterium promotes antitumor immunity and facilitates anti–PD-L1 efficacy

T cell infiltration of solid tumors is associated with favorable patient outcomes, yet the mechanisms underlying variable immune responses between individuals are not well understood. One possible modulator could be the intestinal microbiota. We compared melanoma growth in mice harboring distinct co...

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Veröffentlicht in:Science
Hauptverfasser: Sivan, Ayelet, Corrales, Leticia, Hubert, Nathaniel, Williams, Jason B., Aquino-Michaels, Keston, Earley, Zachary M., Benyamin, Franco W., Lei, Yuk Man, Jabri, Bana, Alegre, Maria-Luisa, Chang, Eugene B., Gajewski, Thomas F.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4873287/
https://ncbi.nlm.nih.gov/pubmed/26541606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aac4255
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