Ubr3, a Novel Modulator of Hh Signaling Affects the Degradation of Costal-2 and Kif7 through Poly-ubiquitination

Hedgehog (Hh) signaling regulates multiple aspects of metazoan development and tissue homeostasis, and is constitutively active in numerous cancers. We identified Ubr3, an E3 ubiquitin ligase, as a novel, positive regulator of Hh signaling in Drosophila and vertebrates. Hh signaling regulates the Ub...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Li, Tongchao, Fan, Junkai, Blanco-Sánchez, Bernardo, Giagtzoglou, Nikolaos, Lin, Guang, Yamamoto, Shinya, Jaiswal, Manish, Chen, Kuchuan, Zhang, Jie, Wei, Wei, Lewis, Michael T., Groves, Andrew K., Westerfield, Monte, Jia, Jianhang, Bellen, Hugo J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4873228/
https://ncbi.nlm.nih.gov/pubmed/27195754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006054
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