Analysis of Paired Primary-Metastatic Hormone-Receptor Positive Breast Tumors (HRPBC) Uncovers Potential Novel Drivers of Hormonal Resistance

We sought to identify genetic variants associated with disease relapse and failure to hormonal treatment in hormone-receptor positive breast cancer (HRPBC). We analyzed a series of HRPBC with distant relapse, by sequencing pairs (n = 11) of tumors (primary and metastases) at >800X. Comparative ge...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Manso, Luis, Mourón, Silvana, Tress, Michael, Gómez-López, Gonzalo, Morente, Manuel, Ciruelos, Eva, Rubio-Camarillo, Miriam, Rodriguez-Peralto, Jose Luis, Pujana, Miguel A., Pisano, David G., Quintela-Fandino, Miguel
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4873174/
https://ncbi.nlm.nih.gov/pubmed/27195705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0155840
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