CXCR2 signaling regulates KRAS((G12D))-induced autocrine growth of pancreatic cancer

Pharmacological inhibition of RAS, the master regulator of pancreatic ductal adenocarcinoma (PDAC), continues to be a challenge. Mutations in various isoforms of RAS gene, including KRAS are known to upregulate CXC chemokines; however, their precise role in KRAS-driven pancreatic cancer remains uncl...

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Spremljeno u:
Bibliografski detalji
Izdano u:Oncotarget
Glavni autori: Purohit, Abhilasha, Varney, Michelle, Rachagani, Satyanarayana, Ouellette, Michel M., Batra, Surinder K., Singh, Rakesh K.
Format: Artigo
Jezik:Inglês
Izdano: Impact Journals LLC 2016
Teme:
Research Paper
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4872785/
https://ncbi.nlm.nih.gov/pubmed/26771140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.6906
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