Activated Kras(G12D) is associated with invasion and metastasis of pancreatic cancer cells through inhibition of E-cadherin

BACKGROUND: Pancreatic cancer (PC) harbours an activated point mutation (Kras(G12D)) in the Kras proto-oncogene that has been demonstrated to promote the development of PC. METHODS: This study was designed to investigate the effect of the oncogenic Kras(G12D) allele on aggressiveness and metastatic...

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Bibliographic Details
Main Authors: Rachagani, S, Senapati, S, Chakraborty, S, Ponnusamy, M P, Kumar, S, Smith, L M, Jain, M, Batra, S K
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2011
Subjects:
Genetics and Genomics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3065271/
https://ncbi.nlm.nih.gov/pubmed/21364589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2011.31
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