Diabetes promotes invasive pancreatic cancer by increasing systemic and tumour carbonyl stress in Kras(G12D/+) mice

BACKGROUND: Type 1 and 2 diabetes confer an increased risk of pancreatic cancer (PaC) of similar magnitude, suggesting a common mechanism. The recent finding that PaC incidence increases linearly with increasing fasting glucose levels supports a central role for hyperglycaemia, which is known to cau...

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Publicat a:J Exp Clin Cancer Res
Autors principals: Menini, Stefano, Iacobini, Carla, de Latouliere, Luisa, Manni, Isabella, Vitale, Martina, Pilozzi, Emanuela, Pesce, Carlo, Cappello, Paola, Novelli, Francesco, Piaggio, Giulia, Pugliese, Giuseppe
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2020
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7418209/
https://ncbi.nlm.nih.gov/pubmed/32778157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-020-01665-0
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