Disruption of KIF3A in patient-derived glioblastoma cells: effects on ciliogenesis, hedgehog sensitivity, and tumorigenesis

KIF3A, a component of the kinesin-2 motor, is necessary for the progression of diverse tumor types. This is partly due to its role in regulating ciliogenesis and cell responsiveness to sonic hedgehog (SHH). Notably, primary cilia have been detected in human glioblastoma multiforme (GBM) tumor biopsi...

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Vydáno v:Oncotarget
Hlavní autoři: Hoang-Minh, Lan B., Deleyrolle, Loic P., Siebzehnrubl, Dorit, Ugartemendia, George, Futch, Hunter, Griffith, Benjamin, Breunig, Joshua J., De Leon, Gabriel, Mitchell, Duane A., Semple-Rowland, Susan, Reynolds, Brent A., Sarkisian, Matthew R.
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2016
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4872766/
https://ncbi.nlm.nih.gov/pubmed/26760767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.6854
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