Disruption of KIF3A in patient-derived glioblastoma cells: effects on ciliogenesis, hedgehog sensitivity, and tumorigenesis

KIF3A, a component of the kinesin-2 motor, is necessary for the progression of diverse tumor types. This is partly due to its role in regulating ciliogenesis and cell responsiveness to sonic hedgehog (SHH). Notably, primary cilia have been detected in human glioblastoma multiforme (GBM) tumor biopsi...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Oncotarget
Prif Awduron: Hoang-Minh, Lan B., Deleyrolle, Loic P., Siebzehnrubl, Dorit, Ugartemendia, George, Futch, Hunter, Griffith, Benjamin, Breunig, Joshua J., De Leon, Gabriel, Mitchell, Duane A., Semple-Rowland, Susan, Reynolds, Brent A., Sarkisian, Matthew R.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Impact Journals LLC 2016
Pynciau:
Research Paper
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4872766/
https://ncbi.nlm.nih.gov/pubmed/26760767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.6854
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