Dual mTOR inhibitor MLN0128 suppresses Merkel cell carcinoma (MCC) xenograft tumor growth

Merkel cell carcinoma (MCC) is an aggressive neuroendocrine skin cancer. Pathologic activation of PI3K/mTOR pathway and elevated expression of c-Myc are frequently detected in MCC. Yet, there is no targeted therapy presently available for this lethal disease. Recently, MLN0128, a second-generation d...

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Bibliographische Detailangaben
Veröffentlicht in:Oncotarget
Hauptverfasser: Kannan, Aarthi, Lin, Zhenyu, Shao, Qiang, Zhao, Stephanie, Fang, Bin, Moreno, Mauricio A., Vural, Emre, Stack, Brendan C., Suen, James Y., Kannan, Krishnaswamy, Gao, Ling
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2015
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4872734/
https://ncbi.nlm.nih.gov/pubmed/26536665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.5878
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