Chronic mTOR activation promotes cell survival in Merkel cell carcinoma

Merkel cell carcinoma (MCC) is an aggressive skin cancer with rising incidence. In this study, we demonstrate that mTOR activation and suppressed autophagy is common in MCCs. mTOR inhibition in two primary human MCC cell lines induces autophagy and cell death that is independent of caspase activatio...

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Detalhes bibliográficos
Main Authors: Lin, Zhenyu, McDermott, Amelia, Shao, Lijian, Kannan, Aarthi, Morgan, Michael, Stack, Brendan C., Moreno, Mauricio, Davis, Daniel A., Cornelius, Lynn A., Gao, Ling
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4080622/
https://ncbi.nlm.nih.gov/pubmed/24262658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2013.11.005
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