Chronic mTOR activation promotes cell survival in Merkel cell carcinoma

Merkel cell carcinoma (MCC) is an aggressive skin cancer with rising incidence. In this study, we demonstrate that mTOR activation and suppressed autophagy is common in MCCs. mTOR inhibition in two primary human MCC cell lines induces autophagy and cell death that is independent of caspase activatio...

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Main Authors: Lin, Zhenyu, McDermott, Amelia, Shao, Lijian, Kannan, Aarthi, Morgan, Michael, Stack, Brendan C., Moreno, Mauricio, Davis, Daniel A., Cornelius, Lynn A., Gao, Ling
Format: Artigo
Jezik:Inglês
Izdano: 2013
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4080622/
https://ncbi.nlm.nih.gov/pubmed/24262658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2013.11.005
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