RNA-Seq of Single Prostate CTCs Implicates Noncanonical Wnt Signaling in Antiandrogen Resistance

Prostate cancer is initially responsive to androgen deprivation, but the effectiveness of androgen receptor (AR) inhibitors in recurrent disease is variable. Biopsy of bone metastases is challenging, hence sampling circulating tumor cells (CTCs) may reveal drug resistance mechanisms. We established...

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Detaylı Bibliyografya
Yayımlandı:Science
Asıl Yazarlar: Miyamoto, David T., Zheng, Yu, Wittner, Ben S., Lee, Richard J., Zhu, Huili, Broderick, Katherine T., Desai, Rushil, Fox, Douglas B., Brannigan, Brian W., Trautwein, Julie, Arora, Kshitij S., Desai, Niyati, Dahl, Douglas M., Sequist, Lecia V., Smith, Matthew R., Kapur, Ravi, Wu, Chin-Lee, Shioda, Toshi, Ramaswamy, Sridhar, Ting, David T., Toner, Mehmet, Maheswaran, Shyamala, Haber, Daniel A.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2015
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4872391/
https://ncbi.nlm.nih.gov/pubmed/26383955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aab0917
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