Effects on the transcriptome upon deletion of a distal element cannot be predicted by the size of the H3K27Ac peak in human cells

Genome-wide association studies (GWAS) have identified single nucleotide polymorphisms (SNPs) associated with increased risk for colorectal cancer (CRC). A molecular understanding of the functional consequences of this genetic variation is complicated because most GWAS SNPs are located in non-coding...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Tak, Yu Gyoung, Hung, Yuli, Yao, Lijing, Grimmer, Matthew R., Do, Albert, Bhakta, Mital S., O'Geen, Henriette, Segal, David J., Farnham, Peggy J.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2016
Assuntos:
Gene regulation, Chromatin and Epigenetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4872074/
https://ncbi.nlm.nih.gov/pubmed/26743005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv1530
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