Impaired endothelial barrier function in apolipoprotein M–deficient mice is dependent on sphingosine-1-phosphate receptor 1

Apolipoprotein M (ApoM) transports sphingosine-1-phosphate (S1P) in plasma, and ApoM-deficient mice (Apom(−/−)) have ∼50% reduced plasma S1P levels. There are 5 known S1P receptors, and S1P induces adherens junction formation between endothelial cells through the S1P(1) receptor, which in turn suppr...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:FASEB J
Autori principali: Christensen, Pernille M., Liu, Catherine H., Swendeman, Steven L., Obinata, Hideru, Qvortrup, Klaus, Nielsen, Lars B., Hla, Timothy, Di Lorenzo, Annarita, Christoffersen, Christina
Natura: Artigo
Lingua:Inglês
Pubblicazione: Federation of American Societies for Experimental Biology 2016
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4871798/
https://ncbi.nlm.nih.gov/pubmed/26956418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201500064
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