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Leishmania-encoded orthologs of macrophage migration inhibitory factor regulate host immunity to promote parasite persistence

Leishmania major encodes 2 orthologs of the cytokine macrophage migration inhibitory factor (MIF), whose functions in parasite growth or in the host–parasite interaction are unknown. To determine the importance of Leishmania-encoded MIF, both LmMIF genes were removed to produce an mif(−/−) strain of...

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Vydáno v:FASEB J
Hlavní autoři: Holowka, Thomas, Castilho, Tiago M., Garcia, Alvaro Baeza, Sun, Tiffany, McMahon-Pratt, Diane, Bucala, Richard
Médium: Artigo
Jazyk:Inglês
Vydáno: Federation of American Societies for Experimental Biology 2016
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4871794/
https://ncbi.nlm.nih.gov/pubmed/26956417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201500189R
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