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Aire enforces immune tolerance by directing autoreactive T cells into the regulatory T cell lineage
The promiscuous expression of tissue-restricted antigens in the thymus, driven in part by Autoimmune Regulator (Aire), is critical for the protection of peripheral tissues from autoimmune attack. Aire-dependent processes are thought to promote both clonal deletion and the development of Foxp3(+) reg...
Gorde:
| Argitaratua izan da: | Immunity |
|---|---|
| Egile Nagusiak: | , , , , , |
| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
2016
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4871732/ https://ncbi.nlm.nih.gov/pubmed/27130899 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2016.02.009 |
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