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Hyperglucagonemia mitigates the effect of metformin on glucose production in prediabetes
The therapeutic mechanism of metformin action remains incompletely understood. Whether metformin inhibits glucagon-stimulated endogenous glucose production (EGP), as in preclinical studies, is unclear in humans. To test this hypothesis, we studied 9 prediabetic individuals using a randomized, placeb...
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| Veröffentlicht in: | Cell Rep |
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| Hauptverfasser: | , , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4871720/ https://ncbi.nlm.nih.gov/pubmed/27160898 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.04.024 |
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