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Hyperglucagonemia mitigates the effect of metformin on glucose production in prediabetes

The therapeutic mechanism of metformin action remains incompletely understood. Whether metformin inhibits glucagon-stimulated endogenous glucose production (EGP), as in preclinical studies, is unclear in humans. To test this hypothesis, we studied 9 prediabetic individuals using a randomized, placeb...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Konopka, Adam R., Esponda, Raul Ruiz, Robinson, Matthew M., Johnson, Matthew L., Carter, Rickey E., Schiavon, Michele, Cobelli, Claudio, Wondisford, Fredric E., Lanza, Ian R., Nair, K. Sreekumaran
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4871720/
https://ncbi.nlm.nih.gov/pubmed/27160898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.04.024
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