TGF-β Small Molecule Inhibitor SB431542 Reduces Rotator Cuff Muscle Fibrosis and Fatty Infiltration By Promoting Fibro/Adipogenic Progenitor Apoptosis

Rotator cuff tears represent a large burden of muscle-tendon injuries in our aging population. While small tears can be repaired surgically with good outcomes, critical size tears are marked by muscle atrophy, fibrosis, and fatty infiltration, which can lead to failed repair, frequent re-injury, and...

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發表在:PLoS One
Main Authors: Davies, Michael R., Liu, Xuhui, Lee, Lawrence, Laron, Dominique, Ning, Anne Y., Kim, Hubert T., Feeley, Brian T.
格式: Artigo
語言:Inglês
出版: Public Library of Science 2016
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4871364/
https://ncbi.nlm.nih.gov/pubmed/27186977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0155486
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