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Primary and Secondary Dimer Interfaces of the FGFR3 Transmembrane Domain: Characterization via Multiscale Molecular Dynamics Simulations

Receptor tyrosine kinases are single pass membrane proteins which form dimers within the membrane. The interactions of their transmembrane domains (TMDs) play a key role in dimerization and signaling. The fibroblast growth factor receptor 3 (FGFR3) is of interest as a G380R mutation in its TMD is th...

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Vydáno v:Biochemistry
Hlavní autoři: Reddy, Tyler, Manrique, Santiago, Buyan, Amanda, Hall, Benjamin A., Chetwynd, Alan, Sansom, Mark S.P.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4871223/
https://ncbi.nlm.nih.gov/pubmed/24397339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi401576k
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