Pasireotide Therapy of Multiple Endocrine Neoplasia Type 1–Associated Neuroendocrine Tumors in Female Mice Deleted for an Men1 Allele Improves Survival and Reduces Tumor Progression

Pasireotide, a somatostatin analog, is reported to have anti-proliferative effects in neuroendocrine tumors (NETs). We therefore assessed the efficacy of pasireotide for treating pancreatic and pituitary NETs that develop in a mouse model of multiple endocrine neoplasia type 1 (MEN1). Men1(+/−) mice...

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Publicat a:Endocrinology
Autors principals: Walls, Gerard V., Stevenson, Mark, Soukup, Benjamin S., Lines, Kate E., Grossman, Ashley B., Schmid, Herbert A., Thakker, Rajesh V.
Format: Artigo
Idioma:Inglês
Publicat: Endocrine Society 2016
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Original Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4870877/
https://ncbi.nlm.nih.gov/pubmed/26990064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2015-1965
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