Pasireotide Therapy of Multiple Endocrine Neoplasia Type 1–Associated Neuroendocrine Tumors in Female Mice Deleted for an Men1 Allele Improves Survival and Reduces Tumor Progression

Pasireotide, a somatostatin analog, is reported to have anti-proliferative effects in neuroendocrine tumors (NETs). We therefore assessed the efficacy of pasireotide for treating pancreatic and pituitary NETs that develop in a mouse model of multiple endocrine neoplasia type 1 (MEN1). Men1(+/−) mice...

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Detalhes bibliográficos
Publicado no:Endocrinology
Main Authors: Walls, Gerard V., Stevenson, Mark, Soukup, Benjamin S., Lines, Kate E., Grossman, Ashley B., Schmid, Herbert A., Thakker, Rajesh V.
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2016
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4870877/
https://ncbi.nlm.nih.gov/pubmed/26990064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2015-1965
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