Islet Hypersensitivity to Glucose Is Associated With Disrupted Oscillations and Increased Impact of Proinflammatory Cytokines in Islets From Diabetes-Prone Male Mice

Pulsatile insulin release is the primary means of blood glucose regulation. The loss of pulsatility is thought to be an early marker and possible factor in developing type 2 diabetes. Another early adaptation in islet function to compensate for obesity is increased glucose sensitivity (left shift) a...

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Vydáno v:Endocrinology
Hlavní autoři: Corbin, Kathryn L., Waters, Christopher D., Shaffer, Brett K., Verrilli, Gretchen M., Nunemaker, Craig S.
Médium: Artigo
Jazyk:Inglês
Vydáno: Endocrine Society 2016
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Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4870867/
https://ncbi.nlm.nih.gov/pubmed/26943366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2015-1879
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