Epigenetically maintained SW13+ and SW13- subtypes have different oncogenic potential and convert with HDAC1 inhibition

BACKGROUND: The BRM and BRG1 tumor suppressor genes are mutually exclusive ATPase subunits of the SWI/SNF chromatin remodeling complex. The human adrenal carcinoma SW13 cell line can switch between a subtype which expresses these subunits, SW13+, and one that expresses neither subunit, SW13-. Loss o...

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Pubblicato in:BMC Cancer
Autori principali: Davis, McKale R., Daggett, Juliane J., Pascual, Agnes S., Lam, Jessica M., Leyva, Kathryn J., Cooper, Kimbal E., Hull, Elizabeth E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2016
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4870788/
https://ncbi.nlm.nih.gov/pubmed/27188282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-016-2353-7
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