Assessing mutant p53 in primary high-grade serous ovarian cancer using immunohistochemistry and massively parallel sequencing

The tumour suppressor p53 is mutated in cancer, including over 96% of high-grade serous ovarian cancer (HGSOC). Mutations cause loss of wild-type p53 function due to either gain of abnormal function of mutant p53 (mutp53), or absent to low mutp53. Massively parallel sequencing (MPS) enables increase...

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Enregistré dans:
Détails bibliographiques
Publié dans:Sci Rep
Auteurs principaux: Cole, Alexander J., Dwight, Trisha, Gill, Anthony J., Dickson, Kristie-Ann, Zhu, Ying, Clarkson, Adele, Gard, Gregory B., Maidens, Jayne, Valmadre, Susan, Clifton-Bligh, Roderick, Marsh, Deborah J.
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2016
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4870633/
https://ncbi.nlm.nih.gov/pubmed/27189670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep26191
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