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An intein-mediated modulation of protein stability system and its application to study human cytomegalovirus essential gene function

Functional analysis of the essential proteins encoded by human cytomegalovirus (HCMV) is hindered by the lack of complementing systems. To overcome this difficulty, we have established a novel approach, termed the intein-mediated modulation of protein stability (imPS), in which a destabilizing domai...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Pan, Deng, Xuan, Baoqin, Sun, Yamei, Huang, Shaowu, Xie, Maorong, Bai, Yadan, Xu, Wenjia, Qian, Zhikang
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4870628/
https://ncbi.nlm.nih.gov/pubmed/27188239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep26167
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