Taselisib (GDC-0032), a Potent β-Sparing Small Molecule Inhibitor of PI3K, Radiosensitizes Head and Neck Squamous Carcinomas Containing Activating PIK3CA Alterations

PURPOSE: Activating PIK3CA genomic alterations are frequent in head and neck squamous cell carcinoma (HNSCC), and there is an association between phosphoinositide 3-kinase (PI3K) signaling and radioresistance. Hence, we investigated the therapeutic efficacy of inhibiting PI3K with GDC-0032, a PI3K i...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Clin Cancer Res
Egile Nagusiak: Zumsteg, Zachary S., Morse, Natasha, Krigsfeld, Gabriel, Gupta, Gaorav, Higginson, Daniel S., Lee, Nancy Y., Morris, Luc, Ganly, Ian, Shiao, Stephan L., Powell, Simon N., Chung, Christine H., Scaltriti, Maurizio, Baselga, José
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2015
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4870591/
https://ncbi.nlm.nih.gov/pubmed/26589432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-15-2245
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