General anesthesia causes epigenetic histone modulation of c-Fos and Brain-derived neurotrophic factor, target genes important for neuronal development in the immature rat hippocampus

BACKGROUND: Early postnatal exposure to general anesthesia (GA) may be detrimental to brain development, resulting in long-term cognitive impairments. Older literature suggests that in utero exposure of rodents to GA causes cognitive impairments in the first- as well as in the second-generation offs...

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Publié dans:Anesthesiology
Auteurs principaux: Massara, Lorenza Dalla, Osuru, Hari Prasad, Oklopcic, Azra, Milanovic, Desanka, Joksimovic, Srdjan Milan, Caputo, Valentina, DiGruccio, Michael Robert, Ori, Carlo, Wang, Guangfu, Todorovic, Slobodan Milenko, Jevtovic-Todorovic, Vesna
Format: Artigo
Langue:Inglês
Publié: 2016
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4870171/
https://ncbi.nlm.nih.gov/pubmed/27028464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/ALN.0000000000001111
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