Calcineurin-inhibition Results in Upregulation of Local Renin and Subsequent Vascular Endothelial Growth Factor Production in Renal Collecting Ducts

BACKGROUND: Tacrolimus (Tac) and Cyclosporine A (CyA) calcineurin inhibitors (CNIs) are 2 effective immunosuppressants which are essential to prevent allograft rejection. Calcineurin inhibitors are known to be nephrotoxic. However, the precise mechanism of nephrotoxicity is not fully understood. In...

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Vydáno v:Transplantation
Hlavní autoři: Prókai, Ágnes, Csohány, Rózsa, Sziksz, Erna, Pap, Domonkos, Balicza-Himer, Leonóra, Boros, Szilvia, Magda, Balázs, Vannay, Ádám, Kis-Petik, Katalin, Fekete, Andrea, Peti-Peterdi, János, Szabó, Attila J.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4870017/
https://ncbi.nlm.nih.gov/pubmed/26502369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/TP.0000000000000961
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